Non-steroidal anti-inflammatory drugs are widely used in the treatment
of inflammatory joint diseases. Many patients suffering from these di
sorders are young women during their childbearing years. We report thr
ee cases of infertility where the cause may have been NSAID-induced 'l
uteinized unruptured follicle' syndrome. This phenomenon is well recog
nized in obstetric circles, and we would like to bring it to the atten
tion of rheumatologists since it is not documented in the rheumatologi
cal literature.