C. Ogutman et al., CARDIOVASCULAR EFFECTS OF INTRATHECALLY INJECTED MU-OPIOID, DELTA-OPIOID AND KAPPA-OPIOID RECEPTOR AGONISTS IN RABBITS, Journal of autonomic pharmacology, 15(6), 1995, pp. 443-450
1. Intrathecal saline, the mu opioid agonist [D-Ala(2), MePhe(4), Gly(
5)-ol] enkephalin (DAGO) and delta opioid agonist [D-Pen(2), D-Pen(5)]
enkephalin (DPDPE) had no significant effects on systemic blood press
ure and heart rate values. 2, The kappa opioid agonist bremazocine how
ever, caused falls in blood pressure and reduction in heart rate. 3, I
ntrathecal administration of saline, DPDPE and bremazocine had no effe
ct on baroreflex sensitivity. 4, Intrathecal administration of DAGO ca
used a reduction in baroreflex sensitivity; this effect was inhibited
by naloxone and abolished after atenolol. 5, The role of spinal opioid
systems as a possible site of action is discussed.