Preclinical management faces considerable diagnostic and therapeutic l
imitations. Patient history, physical examination, and few technical m
eans (electrocardiogram [ECG], blood glucose measurement) must suffice
to arrive at a suspected or definite diagnosis. Emergency treatment o
f most medical conditions inside the hospital differs from the preclin
ical setting. Critically ill patients must be transported to the hospi
tal in emergency units with standardized equipment. Diagnosis of acute
myocardial infarction relies on patient history, present symptoms, an
d a 12-lead ECG, and can be made with relative certainty. Therapeutic
management focuses on reduction of myocardial oxygen consumption and o
ptimizing oxygen availability. Monitoring for possible arrhythmias is
essential. Few exceptional situations justify preclinical thrombolytic
therapy. After a neurologic deficit has been diagnosed, the managemen
t of patients with stroke includes support of vital functions and admi
ssion to a hospital where computed tomography or magnetic resonance im
aging is available. Pulmonary thromboembolism is frequently misdiagnos
ed even in the hospital. Preclinical physical examination, patient his
tory, ECG, and pulse oximetry allow a positive diagnosis only in massi
ve embolization. Anticoagulation with heparin is essential. If cardiop
ulmonary resuscitation is necessary, preclinical thrombolysis may be a
n option. Although deep vein thrombosis is difficult to recognize, cla
ssical symptoms of acute arterial occlusion are rarely missed. Treatme
nt consists of general measures and anticoagulation.