NEUROPEPTIDE-Y (NPY) AND ITS MESSENGER-RNA IN DISCRETE BRAIN-AREAS AFTER SUBCHRONIC ADMINISTRATION OF NEUROLEPTICS

Authors
HERMAN ZS
Citation
Zs. Herman, NEUROPEPTIDE-Y (NPY) AND ITS MESSENGER-RNA IN DISCRETE BRAIN-AREAS AFTER SUBCHRONIC ADMINISTRATION OF NEUROLEPTICS, Acta Neurobiologiae Experimentalis, 56(1), 1996, pp. 55-61
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Acta Neurobiologiae Experimentalis → ACNP
ISSN journal
00651400
Volume
56
Issue
1
Year of publication
1996
Pages
55 - 61
Database
ISI
SICI code
0065-1400(1996)56:1<55:N(AIMI>2.0.ZU;2-Z
Abstract
Classical (chlorpromazine, haloperidol) and atypical (sulpiride and cl ozapine) neuroleptics applied for a period of 2 weeks diminished neuro peptide Y (NPY) levels in nucleus accumbens, but not in striatum. Thes e changes were correlated with NPY mRNA level. However, the effect of these neuroleptics on the level of NPY in hypothalamus was different. It is suggested that changes in NPY levels caused by neuroleptics are mediated by dopaminergic D1/D2 receptors.