PROPYPHENAZONE-INTOLERANCE WITH CLINICAL SYMPTOMS SUGGESTING A LATEX ALLERGY

A 27-year-old surgical nurse developed generalized urticaria and dyspn ea. after wearing latex gloves for a short period of time. However, th e tentative diagnosis of latex allergy could not be proven by latex pr ick testing. Taking the patient's history once again revealed that she had taken a combined preparation of propyphenazone 125 mg, dihydroerg otaminmesilat 0,5 mg and coffein 40 mg (Optalidon special N) seven hou rs before her symptoms began. Since propyphenazone and the other activ e and inactive ingredients of Optalidon special N were negative in pri ck testing we could identify propyphenazone as the causative agent onl y by oral provocation. Other analgesics such as aspirin and paracetamo l were negative in oral provocation tests.