CYTOGENETIC MONITORING OF A GROUP OF ITALIAN FLORICULTURISTS - NO EVIDENCE OF DNA-DAMAGE RELATED TO PESTICIDE EXPOSURE

Authors
SCARPATO R MIGLIORE L ANGOTZI G FEDI A MILIGI L LOPRIENO N
Citation
R. Scarpato et al., CYTOGENETIC MONITORING OF A GROUP OF ITALIAN FLORICULTURISTS - NO EVIDENCE OF DNA-DAMAGE RELATED TO PESTICIDE EXPOSURE, Mutation research. Genetic toxicology testing, 367(2), 1996, pp. 73-82
Citations number
48
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
Mutation research. Genetic toxicology testing → ACNP
ISSN journal
01651218
Volume
367
Issue
2
Year of publication
1996
Pages
73 - 82
Database
ISI
SICI code
0165-1218(1996)367:2<73:CMOAGO>2.0.ZU;2-D
Abstract
The induction of sister chromatid exchanges (SCE), structural chromoso me aberrations (CA) or micronuclei (MN) was investigated in peripheral lymphocytes of a group of Italian floriculturists exposed to a mixtur e of pesticides. No statistically significant difference in the freque ncies of cytogenetic damage was detected between exposed and control s ubjects. Assessment of the effect of confounding factors indicated tha t smoking affected both SCE and CA frequencies, Multiple regression an alysis showed that in heavy smokers (greater than or equal to 20 cigar ettes/day), SCE and CA levels increased significantly by 17% and 54%, respectively, as compared to non-smokers.