INTERLEUKIN-1 (IL1) AND TUMOR-NECROSIS-FACTOR (TNF) SIGNAL-TRANSDUCTION

Authors
SAKLATVALA J DAVIS W GUESDON F
Citation
J. Saklatvala et al., INTERLEUKIN-1 (IL1) AND TUMOR-NECROSIS-FACTOR (TNF) SIGNAL-TRANSDUCTION, Philosophical transactions-Royal Society of London. Biological sciences, 351(1336), 1996, pp. 151-157
Citations number
48
Categorie Soggetti
Biology
Journal title
Philosophical transactions-Royal Society of London. Biological sciences → ACNP
ISSN journal
09628436
Volume
351
Issue
1336
Year of publication
1996
Pages
151 - 157
Database
ISI
SICI code
0962-8436(1996)351:1336<151:I(AT(S>2.0.ZU;2-9
Abstract
The inflammatory cytokines interleukin 1 (IL1) and tumour necrosis fac tor (TNF) have a broad range of physiological effects. Whereas their i mmediate post-receptor events are not well understood, both have the p otential to activate a range of protein kinases. These include the thr ee types of mitogen activated protein (MAP) kinase (ERK,JNK/p54 and p3 8) and a beta-casein kinase. The mechanisms by which these kinases are activated is discussed and the significance of their activation for p articular biological responses is assessed.