J. Saklatvala et al., INTERLEUKIN-1 (IL1) AND TUMOR-NECROSIS-FACTOR (TNF) SIGNAL-TRANSDUCTION, Philosophical transactions-Royal Society of London. Biological sciences, 351(1336), 1996, pp. 151-157
The inflammatory cytokines interleukin 1 (IL1) and tumour necrosis fac
tor (TNF) have a broad range of physiological effects. Whereas their i
mmediate post-receptor events are not well understood, both have the p
otential to activate a range of protein kinases. These include the thr
ee types of mitogen activated protein (MAP) kinase (ERK,JNK/p54 and p3
8) and a beta-casein kinase. The mechanisms by which these kinases are
activated is discussed and the significance of their activation for p
articular biological responses is assessed.