We present the first reported case of vertebral osteomyelitis due to S
taphylococcus lugdunensis. The infection occurred in an 80-year-old wo
man who had been taking glucocorticosteroids. S. lugdunensis is a coag
ulase-negative staphylococcus with considerable potential as a human p
athogen. Isolation of this organism should be regarded as significant
unless evidence suggests otherwise.