GOULD-JACOBS REACTION OF 5-AMINO-2-SUBSTITUTED AND 6-AMINO-2-SUBSTITUTED BENZOXAZOLES .1. REACTION WITH DIETHYL ETHOXYMETHYLENEMALONATE

Reaction of 2-substituted 5- and 6-aminobenzoxazoles 1 and 2 with diet hyl ethoxymethylenemalonate afforded the corresponding diethyl 3-N-(5- and 6-benzoxazolyl)aminomethylenemalonates 3 and 4. Under conditions of the Gould-Jacobs reaction, the compounds 3 gave a mixture of angula rly and linearly annelated oxazolo[4,5-f]quinolones 5 and oxazolo[5,4- g]quinolones 6, and compounds 4 afforded a mixture of oxazolo[5,4-f]qu inolones 7 and oxazolo[4,5-g]quinolones 8.