TOXICITY OF BUSULFAN AND CYCLOPHOSPHAMIDE (BU CY2) IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES/

Between July 1991 and January 1994, 52 patients with hematologic malig nancies underwent BMT using BU/CY2 as conditioning regimen, Median pat ient age was 38 years, Eleven patients underwent autologous BMT, 22 HL A-identical allogeneic BMT, and 19 patients underwent a MUD or an allo geneic mismatched BMT, GVHD prophylaxis was with cyclosporine/methylpr ednisone in 26 patients; T cell depletion was used in 15 patients, VOD was observed in 7.5% of patients, IP in 12%, seizures in 4%, The over all incidence of grade II-IV acute GVHD was 35%, Delayed platelet engr aftment was observed in seven of 11 patients who underwent autologous BMT, Graft failure was seen in seven of 19 (37%) patients who underwen t MUD or allogeneic mismatched BMT, Six of the seven patients received T cell depletion as GVHD prophylaxis. BU/CY2 transplantation from an unrelated or family-mismatched donor with T cell depletion is associat ed with a high incidence of graft failure.