HEMATOPOIETIC CLONE WITH KARYOTYPIC ABNORMALITIES OF HOST ORIGIN AFTER BONE-MARROW TRANSPLANTATION - 2 CASE-REPORTS

A patient with non-Hodgkin's lymphoma in remission developed a myelody splastic syndrome (MDS) 12 years after ABMT, This patient had undergon e bone marrow harvesting prior to any chemoradiotherapy, He had receiv ed the autograft following conditioning with high-dose CY and TBI, Chr omosomal analysis of BM cells revealed complicated abnormalities, Simi lar karyotypic abnormalities in host-derived BM cells were found in an other patient with AML who had received allogeneic BM following condit ioning with CY plus TBI 15 months previously, These findings suggest t hat MDS or clonal karyotypic abnormalities following ABMT may derive f rom endogenous hematopoietic stem cells that survive the BMT preparati ve regimen.