SPONTANEOUS PREGNANCIES DESPITE FAILED ATTEMPTS AT OVULATION INDUCTION IN A WOMAN WITH IATROGENIC PREMATURE OVARIAN FAILURE - A CASE-REPORT

BACKGROUND: Women with premature ovarian fail true may conceive sponta neously or following different regimens of ovulation induction. CASE: A 29-year-old woman with eight years of hypergonadotropic hypogonadism following chemotherapy and radiotherapy for Hodgkin's disease conceiv ed spontaneously and spontaneously aborted after discontinuation of es trogen replacement. Subsequently she underwent pituitary gonadotrope d ownregulation and attempted controlled ovarian hyperstimulation withou t an ovarian response or follicular development. Despite this failure, she conceived spontaneously on two occasions, resulting in a live-bor n infant and an ongoing pregnancy. CONCLUSION: Cases of hypergonadotro pic hypogonadism may not be permanent or irreversible. Interventional regimens may fail to induce ovulation despite the presence of residual oocytes capable of recruitment and fertilization.