HUCKEBEIN IS REQUIRED FOR GLIAL DEVELOPMENT AND AXON PATHFINDING IN THE NEUROBLAST-1-1 AND NEUROBLAST-2-2 LINEAGES IN THE DROSOPHILA CENTRAL-NERVOUS-SYSTEM

huckebein encodes a predicted zinc finger transcription factor which i s transiently expressed in a subset of Drosophila central nervous syst em precursors (neuroblasts (NBs)). We used DiI cell lineage tracing an d cell fate markers to investigate the role of huckebein in the NE 1-1 and NE 2-2 cell lineages. Loss of huckebein does not switch these NBs into different NE fates, nor does it change the number of cells in th eir lineages; rather, it is required for glial development in the NE 1 -1 lineage, and for axon pathfinding of a subset of interneurons and m otoneurons in both lineages.