Js. Michaelson et al., B-CELL LINEAGE-SPECIFIC ACTIVATOR PROTEIN (BSAP) - A PLAYER AT MULTIPLE STAGES OF B-CELL DEVELOPMENT, The Journal of immunology, 156(7), 1996, pp. 2349-2351
B cell lineage-specific activator protein (BSAP), encoded by the Pax 5
gene, is a critical modulator of early B cell differentiation, Bindin
g sites for BSAP have been identified in the promoters of multiple gen
es as well as at multiple sites within the IgH locus, While in vivo ta
rget sites critical for early B cell differentiation have not yet been
identified, candidate sites include a 3' IgH enhancer that is active
early in B cell development, BSAP may play an additional role later in
development, such as in the regulation of isotype class switching.