IN-VITRO ACTIVITY OF CARBAPENEM ANTIBIOTICS AGAINST BETA-LACTAM SUSCEPTIBLE AND RESISTANT STRAINS OF BURKHOLDERIA-PSEUDOMALLEI

Authors
SMITH MD WUTHIEKANUN V WALSH AL WHITE NJ
Citation
Md. Smith et al., IN-VITRO ACTIVITY OF CARBAPENEM ANTIBIOTICS AGAINST BETA-LACTAM SUSCEPTIBLE AND RESISTANT STRAINS OF BURKHOLDERIA-PSEUDOMALLEI, Journal of antimicrobial chemotherapy, 37(3), 1996, pp. 611-615
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
37
Issue
3
Year of publication
1996
Pages
611 - 615
Database
ISI
SICI code
0305-7453(1996)37:3<611:IAOCAA>2.0.ZU;2-P
Abstract
Four carbapenem antibiotics were tested for their in-vitro activities (MICs, MBCs and time-kill studies) against Burkholderia pseudomallei. The carbapenems were all more active than either ceftazidime or co-amo xiclav against strains of B. pseudomallei with a normal susceptibility pattern. Biapenem was the most active antibiotic tested. All four car bapenems retained bactericidal activity against 24 strains of B. pseud omallei with reduced susceptibility to ceftazidime and/or co-amoxiclav .