PROTECTION STUDIES AGAINST MAREKS-DISEASE USING BACULOVIRUS-EXPRESSEDGLYCOPROTEIN-B AND GLYCOPROTEIN-C OF MAREKS-DISEASE VIRUS TYPE-1

Authors
JANG HK KITAZAWA T ONO M KAWAGUCHI Y MAEDA K YOKOYAMA N TOHYA Y NIIKURA M MIKAMI T
Citation
Hk. Jang et al., PROTECTION STUDIES AGAINST MAREKS-DISEASE USING BACULOVIRUS-EXPRESSEDGLYCOPROTEIN-B AND GLYCOPROTEIN-C OF MAREKS-DISEASE VIRUS TYPE-1, Avian pathology, 25(1), 1996, pp. 5-24
Citations number
61
Categorie Soggetti
Veterinary Sciences
Journal title
Avian pathology → ACNP
ISSN journal
03079457
Volume
25
Issue
1
Year of publication
1996
Pages
5 - 24
Database
ISI
SICI code
0307-9457(1996)25:1<5:PSAMUB>2.0.ZU;2-W
Abstract
Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus typ e 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were inv estigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV- expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immun ization of chickens with rAcNPV-expressed MDV1-gC induced antibody aga inst MDV1, but failed to protect against challenge with the virulent M DV1. Go-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC se emed to show no synergistic effect.