CASE-REPORT ON CLINICAL AND PATHOPHYSIOLO GICAL SIMILARITIES IN MOSCHCOWITZS DISEASE AND HELLP-SYNDROME

This case report describes for the first time a manifestation of throm botic thrombocytopenic purpura (TTP, Moschcowitz's disease) during pre gnancy. The characteristic neurologic symptoms of TTP were missing, wh ile the typical clinical signs of the HELLP syndrome could be observed . Furthermore the biochemical proof of TTP was obtained by tracing ult ralarge clotting factor VIII (von Willebrand factor) multimers in the patient's plasma. Thus the assumption is supported that TTP and HELLP syndrome are diseases of one pathophysiological entity with different symptomatologies. Because of the frequent relapse of TTP, differentiat ion between TTP and HELLP syndrome is of great clinical importance, in dependent of future pregnancies.