THE APO-B GENE ENCODING PUTATIVE LOW-DENS ITY-LIPOPROTEIN RECEPTOR-BINDING DOMAIN OF THE APO-B-100 PROTEIN SHOWS NO DNA POLYMORPHISMS

To reveal the molecular basis of hereditary diathesis to hypercholeste rolemia, single-strand conformation polymorphism (SSCP) analysis and s ubsequent sequencing were used to study structural organization of the APOB. gene for apolipoprotein B-100 (ApoB-100). The gene region encod ing a putative low density lipoprotein (LDL) receptor binding domain w as analyzed in patients with myocardial infarction (MI). Differences i n structure of the gene between patients with MI and healthy people we re not detected.