Tf. Hoffmann et al., PROTECTIVE EFFECT OF THE SOMATOSTATIN ANALOG OCTREOTIDE IN ISCHEMIA REPERFUSION-INDUCED ACUTE-PANCREATITIS IN RATS, Pancreas, 12(3), 1996, pp. 286-293
Somatostatin and its stable analogue octreotide are proposed to amelio
rate the outcome from acute pancreatitis by inhibiting pancreatic secr
etion and preventing cell injury. This study investigated the effect o
f somatostatin analogue octreotide on pancreatic microcirculatory inju
ry (by means of intravital fluorescence microscopy) and enzyme release
after ischemia/reperfusion of the pancreas in rats. Octreotide, injec
ted 15 min before the end of 2 h of ischemia as a bolus injection (50
mu g kg(-1) i.v.) or as a continuous infusion (50 mu g kg(-1) h(-1) i.
v.), attenuated postischemic reperfusion injury of the pancreas as evi
denced by a significant (p < 0.05) improvement in capillary perfusion
and decrease in leukocyte-endothelium interaction in postcapillary ven
ules compared to ischemia without treatment. Pancreas amylase concentr
ation remained unchanged in the octreotide group but increased signifi
cantly (p < 0.05) in the ischemia group. These results indicate a prot
ective effect of octreotide against postischemic reperfusion injury of
the pancreas in rats.