Background: The drug-assisted interview appears to be declining in psy
chiatric practice. This decline may be due in part to complexities in
the use of barbiturates, which have a narrow therapeutic index. Method
: Five patients who had depression and/or posttraumatic stress disorde
r underwent drug-assisted interviews for which midazolam and pulse oxi
metry monitoring were used. Results: The midazolam-pulse oximetry tech
nique resulted in consistent and easily monitored levels of conscious
sedation. Midazolam was judged comparably effective to amobarbital and
easier to use. Conclusion: A simple, safe, and effective technique fo
r drug-assisted interviewing for which midazolam and continuous pulse
oximetry monitoring are used is described.