THE DEVELOPMENT OF IN-VIVO TRACER METHODS TO OBTAIN NEW INFORMATION ABOUT HUMAN-DISEASE - A STUDY OF THE HALLUCINATING BRAIN

An outline is provided of the development of methodological strategies to address the question of focal cerebral activation during hallucina tions in schizophrenic patients. In so doing, the innovation and dilig ence required to tailor in vivo tracer procedures to specific clinical research issues are highlighted. Attention is drawn to the complexity of methodological advances and the way in which they are based upon c lose scientific and technical collaboration between clinical scientist s, and non-clinical scientists and research support staff.