SYNTHESIS, CHARACTERIZATION, AND ANTITUMOR-ACTIVITY OF A SERIES OF NOVEL CISPLATIN ANALOGS WITH CIS-1,4-DIAMINOCYCLOHEXANE AS NONLEAVING AMINE GROUP

A series of novel platinum(II) complexes of the type Pt-II(cis-1,4-DAC H)X (where cis-1,4-DACH = cis-1,4-diaminocyclohexane and X = dichloro, sulfate, oxalato, malonato, methylmalonato, tartronato, or 1,1-cyclob utanedicarboxylato [CBDCA) ligand and novel platinum(IV) complexes of the types Pt-IV(cis-1,4-DACH)trans(Y)(2)Cl-2 (where Y = chloro, hydrox o, acetato, propionato, or butyrato ligand) and Pt-IV(cis-1,4-DACH)tra ns(Cl)(2)(X) (where X = oxalato or CBDCA ligand) were synthesized and characterized by elemental analysis, infrared, and Pt-195 NMR spectros copic techniques. Platinum complexes had good in vitro cytotoxic activ ity against murine leukemia L1210/0 (IC50 = 0.0032 - 1.60 mu M) and hu man ovarian A2780 (IC50 = 0.045 - 0.430 mu M) cell lines.