C. Charpin et al., COMPARISON OF THE PROGNOSTIC-SIGNIFICANCE OF CURRENT AND MODIFIED HISTOLOGICAL GRADES IN BREAST CARCINOMAS, Anticancer research, 15(6B), 1995, pp. 2611-2617
Paraffin sections of 185 breast carcinomas were reexamined in order to
compare the current SBR histoprognostic grade (SBR) with to modified
methods of grading recently proposed by two groups, Le Doussal et al (
MSBR) and Elston et al (SBR-Elston). In each tumor, the SBR, MSBR, SBR
-Elston, and each of their components were correlated with recurrence,
metastases and survival rates (follow up 7 to 96 months, m = 52, SD =
19) (Kaplan-Meier test). The Nottingham prognostic index (NPI) was co
mputed for each patient, the histological type reevaluated and both we
re also correlated with the patient follow up. Our results show that t
he three methods of grading were significantly (p < 0.0001) correlated
. The three grades, were significantly correlated with metastases and
survival, but not with the recurrence rates. The differentiation, the
nuclear pleomorphism and the mitoses count also correlated with the me
tastases rate and overall survival but the mitosis number appeared to
be a stronger prognostic indicator. The MSBR grading made it possible
to refine the prognostic of the tumors usually scored as SBR grade 2.
The NPI significantly correlated with metastases and survival (p < 0.0
001), whereas the histological types were found to have no prognostic
significance.