EFFICIENT SYNTHESIS OF A-CHLORO KETONES VIA REACTION OF ORGANOMETALLIC REAGENTS WITH N-METHOXY-N-METHYLCHLOROACETAMIDE

Authors
TILLYER R FREY LF TSCHAEN DM DOLLING UH
Citation
R. Tillyer et al., EFFICIENT SYNTHESIS OF A-CHLORO KETONES VIA REACTION OF ORGANOMETALLIC REAGENTS WITH N-METHOXY-N-METHYLCHLOROACETAMIDE, Synlett, (3), 1996, pp. 225
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
3
Year of publication
1996
Database
ISI
SICI code
0936-5214(1996):3<225:ESOAKV>2.0.ZU;2-R
Abstract
A simple, high yielding synthesis of alpha-chloro ketones is described , involving acylation of Grignard and organolithium reagents with N-me thoxy-N-methylchloroacetamide. The efficiency of the process is furthe r enhanced by recycling N,O-dimethylhydroxylamine.