PHARMACOKINETICS OF DEXAMETHASONE IN PREMATURE NEONATES

Objective: Dexamethasone is frequently used in premature neonates with bronchopulmonary dysplasia, however little is known about its disposi tion in this population. Methods: We evaluated the pharmacokinetics of dexamethasone in 9 premature neonates with a mean gestational age of 27.3 weeks and a postnatal age of 21.8 days. Results: There was a stro ng relationship between clearance (4.96 ml . min(-1)kg(-1)) and gestat ional age (r = 0.884). Pharmacokinetic parameters were grouped based o n a gestational age of less than 27 weeks (Group I) and greater than 2 7 weeks (Group II). Mean clearance in group I and group II was 1.69 an d 7.57 ml . min(-1)kg(-1), respectively. Mean distribution volume in g roup I and II was 1.26 and 2.19 1 . kg(-1) respectively. No significan t relationships were noted between the disposition of dexamethasone an d ventilator requirements or adverse effects. Conclusion: The pharmaco kinetics of dexamethasone in premature neonates was related to gestati onal age.