SYNTHESIS OF 6,6-DICARBOXY-3,4-METHANO-L-PROLINE, A NEW CONSTRAINED GLUTAMATE ANALOG ENDOWED WITH NEUROPROTECTIVE PROPERTIES

Authors
MARINOZZI M NATALINI B COSTANTINO G PELLICCIARI R BRUNO V NICOLETTI F
Citation
M. Marinozzi et al., SYNTHESIS OF 6,6-DICARBOXY-3,4-METHANO-L-PROLINE, A NEW CONSTRAINED GLUTAMATE ANALOG ENDOWED WITH NEUROPROTECTIVE PROPERTIES, Il Farmaco, 51(2), 1996, pp. 121-124
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
2
Year of publication
1996
Pages
121 - 124
Database
ISI
SICI code
0014-827X(1996)51:2<121:SO6ANC>2.0.ZU;2-T
Abstract
6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by t he rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazom alonate in the presence of a 3,4-didehydroproline derivative. When eva luated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity.