SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME IMIDAZOLINYL-PYRAZOLEDERIVATIVES

Some new imidazolinyl-pyrazoles (4) were synthesized by condensation o f 2-imidazolylhydrazine hydroiodid (la) with beta-ketoesters to afford the intermediate 3 that, as free base, ring closes only to 4. The att empt to obtain the imidazo-triazepinone 5, starting from 2-imidazoliny l-2-methylhydrazine, was accomplished, in low yield, only in reacting with ethyl acetoacetate. The pharmacological evaluation of antiinflamm atory and analgesic activities of pyrazoles 4a-f revealed an appreciab le antiinflammatory activity.