NEW HETERO-ANNELATION REACTIONS USING N-[BIS-(METHYLTHIO)-METHYLENE]-AMINO AND RELATED REAGENTS

Reaction of acyclic (R(1-3)) and cyclic (R(4-5)) BMMA (=N-[bis-(methyl thio)-methylene]-amino) reagents with Gewald-type thiophene derivative s (2, 3) led to annelation of pyrimidine moieties. Thus, linear thiazo lo- or thiazino- and pyrrolo-, pyrido- or azepino-fused thiopyrano[4', 3':4,5]thieno-[2,3-d]pyrimidines (5 and 6) as well as the angular imid azo-fused thiopyrano[4,'3':4,5]thieno-[2,3-d]pyrimidine 8 were easily obtained from one-pot reactions in good yields.