A NONPEPTIDIC PHOTOACTIVATABLE ANTAGONIST FOR MAPPING THE ANTAGONIST BINDING-SITE OF THE TACHYKININ NK2 RECEPTOR

Authors
KERSEY ID BHOGAL N DONNELLY D FISHWICK CWG FINDLAY JBC WARD P
Citation
Id. Kersey et al., A NONPEPTIDIC PHOTOACTIVATABLE ANTAGONIST FOR MAPPING THE ANTAGONIST BINDING-SITE OF THE TACHYKININ NK2 RECEPTOR, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 605-608
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
6
Year of publication
1996
Pages
605 - 608
Database
ISI
SICI code
0960-894X(1996)6:6<605:ANPAFM>2.0.ZU;2-Q
Abstract
SR 48968, amido-4-phenylpiperidinyl)-2S-(3,4-dichlorophenyl) butyl]ben zamide is a potent and selective non-peptidic antagonist of the NK2 re ceptor. A photoactivatable analogue containing a diazirine moiety also binds with high affinity, This compound is potentially useful for ide ntifying residues at the antagonist binding site of the NK2 receptor.