THIOPHENOXY PEPTIDES - A NEW CLASS OF HIV REPLICATION INHIBITORS

Authors
NIDDAM V CAMPLO M LENGUYEN D CHERMANN JC KRAUS JL
Citation
V. Niddam et al., THIOPHENOXY PEPTIDES - A NEW CLASS OF HIV REPLICATION INHIBITORS, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 609-614
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
6
Year of publication
1996
Pages
609 - 614
Database
ISI
SICI code
0960-894X(1996)6:6<609:TP-ANC>2.0.ZU;2-8
Abstract
A new series of modified peptides inhibitors of HIV is reported. These peptides utilize the isosteric substitution of a methylene group by a sulfur atom in a phenylalanine residue. Two thiophenoxy peptides 9 an d 11 inhibit in vitro HIV-1 replication in MT(4) cells with IC50 value s of 5 and 10 mu M respectively.