SYNTHESIS OF POLYAMIDE NUCLEIC-ACIDS (PNAS) USING A NOVEL FMOC MMT PROTECTING-GROUP COMBINATION/

Authors
BREIPOHL G KNOLLE J LANGNER D OMALLEY G UHLMANN E
Citation
G. Breipohl et al., SYNTHESIS OF POLYAMIDE NUCLEIC-ACIDS (PNAS) USING A NOVEL FMOC MMT PROTECTING-GROUP COMBINATION/, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 665-670
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
6
Year of publication
1996
Pages
665 - 670
Database
ISI
SICI code
0960-894X(1996)6:6<665:SOPN(U>2.0.ZU;2-E
Abstract
The preparation of 9-Fluorenylmethoxycarbonyl(Fmoc) protected building blocks for the synthesis of polyamide nucleic acids (PNAs) is describ ed. Use of 4-Methoxyphenyldiphenylmethyl (Mmt)-protecting groups for t he exocyclic amino function of the nucleobases enhances the solubility of the monomers and allows final deprotection by mild acid treatment. The novel synthetic route is exemplified by the synthesis of heptamer ic and octameric PNAs.