SYNTHESIS AND ANTITUMOR-ACTIVITY OF A NEW CLASS OF WATER-SOLUBLE CAMPTOTHECIN DERIVATIVES

Authors
BEDESCHI A ZARINI F CABRI W CANDIANI I PENCO S CAPOLONGO L CIOMEI M FARAO M GRANDI M
Citation
A. Bedeschi et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF A NEW CLASS OF WATER-SOLUBLE CAMPTOTHECIN DERIVATIVES, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 671-674
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
6
Year of publication
1996
Pages
671 - 674
Database
ISI
SICI code
0960-894X(1996)6:6<671:SAAOAN>2.0.ZU;2-5
Abstract
A new family of water soluble camptothecin derivatives is described. T heir synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.