SYNTHESIS AND EVALUATION OF 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES AS C1R SERINE-PROTEASE INHIBITORS

Authors
GILMORE JL HAYS SJ CAPRATHE BW LEE C EMMERLING MR MICHAEL W JAEN JC
Citation
Jl. Gilmore et al., SYNTHESIS AND EVALUATION OF 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES AS C1R SERINE-PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 679-682
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
6
Year of publication
1996
Pages
679 - 682
Database
ISI
SICI code
0960-894X(1996)6:6<679:SAEO2A>2.0.ZU;2-3
Abstract
A series of 2-aryl-4H-3,1-benzoxazin-4-ones have been synthesized and tested for inhibitory activity against Clr serine protease. Compounds were found that were equipotent and more selective than the reference compound FUT-175.