EVALUATION OF TEA POLYPHENOLS AS ANTI-HIV AGENTS

Authors
HASHIMOTO F KASHIWADA Y NONAKA G NISHIOKA I NOHARA T COSENTINO LM LEE KH
Citation
F. Hashimoto et al., EVALUATION OF TEA POLYPHENOLS AS ANTI-HIV AGENTS, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 695-700
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
6
Year of publication
1996
Pages
695 - 700
Database
ISI
SICI code
0960-894X(1996)6:6<695:EOTPAA>2.0.ZU;2-L
Abstract
Thirty-eight tea polyphenols were evaluated for their inhibitory effec t against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (-)-epi gallocatechin (13) and theasinensin-D (32) demonstrated relatively pot ent anti-HIV activity with EC(50) values of 4 and 8 mu g/mL and therap eutic indexes of 9.5 and 5, respectively.