BIOAVAILABILITY, METABOLISM AND PHYSIOLOGICAL IMPACT OF 4-OXO-FLAVONOIDS

4-oxo-flavonoids are dietary compounds widely distributed in the plant kingdom. Interest in these substances has arisen because of possible effects on human health. Indeed, in spite of extensive metabolism by t he intestinal flora, 4-oxo-flavonoids seem to be sufficiently absorbed to have physiological effects. This review discusses the possibilitie s of a positive role in cardiovascular disease and cancer prevention, particularly by their antioxidant properties and their ability to modu late the activity of many enzymes, and summarizes the data concerning an eventual carcinogenicity of 4-oxo-flavonoids.