CLINICAL-STUDIES OF IRON CHELATORS IN MALARIA

In 75 Zambian and Thai subjects with mild to moderate infection with P lasmodium falciparum or Plasmodium vivax, 3-day infusions of desferrio xamine B (100 mg/kg/day) as a single agent enhanced the clearance of a sexual peripheral blood parasites, but recrudescence occurred in most subjects. In 83 Zambian children with cerebral malaria who were random ized to receive desferrioxamine B or placebo in addition to standard q uinine-based therapy as part of a prospective double-blind trial, both parasite clearance and recovery from coma were faster with administra tion of the iron chelator. Retrospective studies in the children with cerebral malaria raised the possibility that, in addition to withholdi ng iron from the parasite, desferrioxamine B may have enhanced the T h elper 1 immune response and protected against iron-mediated peroxidant cerebral tissue damage.