SCEDOSPORIUM PROLIFICANS SCLEROKERATITIS

Background: The fungus Scedosporium prolificans was first described as a human pathogen in 1984, and has been associated with metastatic end ophthalmitis and one previously reported case of sclerokeratitis. Meth ods: We report a case of S. prolificans sclerokeratitis in the setting of late scleral necrosis complicating pterygium surgery with adjuncti ve beta-irradiation. Results: A poor clinical response to topical nata mycin and amphotericin B, and systemic itraconazole and ketoconazole w as encountered. Enucleation was required, with subsequent microbiologi cal cure. Pathological correlation is described. Conclusions: S. proli ficans infections often respond poorly to medical therapy. Early surgi cal intervention is indicated in culture-proven scleritis due to Scedo sporium prolificans.