W. Mamo et al., VACCINATION WITH STAPHYLOCOCCUS-AUREUS FIBRINOGEN BINDING-PROTEINS (FGBPS) REDUCES COLONIZATION OF STAPHYLOCOCCUS-AUREUS IN A MOUSE MASTITIS MODEL, FEMS immunology and medical microbiology, 10(1), 1994, pp. 47-53
A mouse mastitis model was used to study the effect of vaccination wit
h fibrinogen binding proteins and collagen binding protein from Staphy
lococcus aureus against challenge infection with S. aureus. The mice v
accinated with fibrinogen binding proteins showed reduced rates of mas
titis compared with controls. Gross examination of challenged mammary
glands of mice showed that the glands of mice immunized with fibrinoge
n binding proteins developed mild intramammary infection or had no pat
hological changes compared with glands from control mice. Histopatholo
gical examination of tissue sections from challenged glands showed tha
t most glands from mice vaccinated with fibrinogen binding protein dev
eloped disseminated necrosis or had no pathological changes. A signifi
cantly reduced number of bacteria could be recovered in the glands fro
m mice immunized with fibrinogen binding proteins as compared with con
trols. In a similar study, immunization of mice with collagen binding
protein did not induce protection against challenge infection with S.
aureus.