INHIBITION OF THE RESPIRATORY BURST IN MOUSE MACROPHAGES BY ULTRA-LOWDOSES OF AN OPIOID PEPTIDE IS CONSISTENT WITH A POSSIBLE ADAPTATION MECHANISM

Authors
EFANOV AM KOSHKIN AA SAZANOV LA BORODULINA OI VARFOLOMEEV SD ZAITSEV SV
Citation
Am. Efanov et al., INHIBITION OF THE RESPIRATORY BURST IN MOUSE MACROPHAGES BY ULTRA-LOWDOSES OF AN OPIOID PEPTIDE IS CONSISTENT WITH A POSSIBLE ADAPTATION MECHANISM, FEBS letters, 355(2), 1994, pp. 114-116
Citations number
11
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
355
Issue
2
Year of publication
1994
Pages
114 - 116
Database
ISI
SICI code
0014-5793(1994)355:2<114:IOTRBI>2.0.ZU;2-8
Abstract
The respiratory burst induced by phorbol myristate acetate in mouse ma crophages was inhibited by ultra-low doses (10(-15)-10(-13) M) of an o pioid peptide [D-Ala(2)]methionine enkephalinamide. The effect disappe ared at concentrations above and below this range. The inhibition appr oached 50% and was statistically significant (P < 0.001). Increasing t he time of the opioid incubation with cells brought about a shift in t he maximal effect to lower concentrations of the opioid (from 10(-13) to 5.10(-15) M) and led to a decrease in the value of the effect, full y in accord with the previously proposed adaptation mechanism of the a ction of ultra-low doses.