RAPID DETECTION OF RH(D)-POSITIVE OR K-POSITIVE FETAL RED-CELLS IN CHORION VILLUS SAMPLES BY A FLOW CYTOMETRIC TECHNIQUE

Rh(D)- and K-negative women who have become severely isoimmunized by p regnancy are at risk of fetal loss or damage in subsequent pregnancies . A flow cytometric method is described whereby the presence of Rh(D) or K antigen on fetal erythrocytes may be determined using chorion vil lus samples taken during the first trimester. this method has the adva ntage of speed and sensitivity with results being available within 2h. Decisions as to management of the pregnancy or termination may thus b e made with minimal delay.