A differential diagnosis of inflammatory periocular soft tissue masses
includes sarcoidosis, ruptured dermoid cyst, infectious abscess, meta
static neoplastic disease, and idiopathic pseudotumor. The authors pre
sent the case of a 42-year-old woman with a periocular inflammatory ma
ss caused by dirofilaria of a nematode classification as Dirofilaria t
enuis. The extraction of the worm was curative and the patient has bee
n symptom-free for the ensuing 12 months. This zoonotic infection, spr
ead by mosquito vectors from animal hosts to humans, is rarely encount
ered in the United States as a cause of periorbital inflammation. A hi
story of migratory swelling and residence in, or travel to, endemic ar
eas (the southeastern United States) should suggest the possibility of
Dirofilaria infection.