LOCALIZATION OF 4 ANTIGENIC SITES INVOLVED IN VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS PROTECTION

Authors
AGAPOV EV RAZUMOV IA FROLOV IV KOLYKHALOV AA NETESOV SV LOKTEV VB
Citation
Ev. Agapov et al., LOCALIZATION OF 4 ANTIGENIC SITES INVOLVED IN VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS PROTECTION, Archives of virology, 139(1-2), 1994, pp. 173-181
Citations number
24
Categorie Soggetti
Virology
Journal title
Archives of virology → ACNP
ISSN journal
03048608
Volume
139
Issue
1-2
Year of publication
1994
Pages
173 - 181
Database
ISI
SICI code
0304-8608(1994)139:1-2<173:LO4ASI>2.0.ZU;2-A
Abstract
Stable neutralization and protection escape variants of a virulent str ain (Trinidad Donkey) of the VEE virus were selected by monoclonal ant ibodies (MAbs). Determination of nucleotide sequences of nine variants revealed a clustering of single mutations in four regions of the El a nd E2 glycoproteins. Involvement of amino acid residues 206 (site El-l ), 57 and 59 (site E2-2), 180, 182, 213, 214 and 216 (site E2-6) and 2 32 (site E2-3) in protective epitopes was demonstrated.