EFFECT OF AN ANXIOLYTIC ON LIPID PROFILE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS

The effects on serum lipid levels of reducing stress were examined in 20 patients with non-insulin-dependent diabetes mellitus. An anxiolyti c, fludiazepam, was administered to the patients for 12 weeks and thei r lipid profiles and State-Trait Anxiety Inventory scores at the begin ning and end of treatment were compared. The high-density lipoprotein cholesterol level increased significantly after the administration of anxiolytic, but other aspects of the lipid profile were unchanged. Bot h trait and state anxiety scores decreased significantly with the admi nistration of anxiolytic. The results indicate that improvement of str ess in patients with non-insulin-dependent diabetes mellitus increases high-density lipoprotein levels.