GENERALIZED CONSENSUS MATRIX FOR RECOGNITION OF CLEAVAGE POLYADENYLATION SITES IN VERTEBRATE PRE-MESSENGER-RNA/

Citation
Yv. Kondrakhin et Vv. Shamin, GENERALIZED CONSENSUS MATRIX FOR RECOGNITION OF CLEAVAGE POLYADENYLATION SITES IN VERTEBRATE PRE-MESSENGER-RNA/, Molecular biology, 28(3), 1994, pp. 338-343
Citations number
23
Categorie Soggetti
Biology
Journal title
ISSN journal
00268933
Volume
28
Issue
3
Year of publication
1994
Part
1
Pages
338 - 343
Database
ISI
SICI code
0026-8933(1994)28:3<338:GCMFRO>2.0.ZU;2-T
Abstract
A sample of 63 sequences of the cleavage/polyadenylation sites in vert ebrate pre-mRNA was used to construct a generalized consensus matrix, composed of the absolute frequencies of oligonucleotides of length l i n the ith position relative to the cleavage point. To recognize a poly adenylation site in a nucleotide sequence, a multiplicative measure wa s obtained using the matrical elements as weighing factors. For any om ega-long segment, comparison of the functional mu with the threshold v alue mu permits one to judge whether the given segment is a processin g site.