STUDIES ON THE OXIDATIVE ADDITION OF N,N-DIMETHYLAMINE TO BROMOJUGLONES AND BROMOMETHYLJUGLONES

Authors
CHAKER L PAUTET F FILLION H
Citation
L. Chaker et al., STUDIES ON THE OXIDATIVE ADDITION OF N,N-DIMETHYLAMINE TO BROMOJUGLONES AND BROMOMETHYLJUGLONES, Chemical and Pharmaceutical Bulletin, 42(11), 1994, pp. 2238-2240
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
11
Year of publication
1994
Pages
2238 - 2240
Database
ISI
SICI code
0009-2363(1994)42:11<2238:SOTOAO>2.0.ZU;2-1
Abstract
The nucleophilic addition of dimethylamine to bromojuglones and bromom ethyljuglones is followed by elimination of hydrogen bromide or oxidat ion. With 2-bromojuglone, the oxidative process predominates at low te mperature. The regiochemistry of the addition is a function of the tem perature and of the position of the bromine atom (C-2 or C-3) on the q uinone.