SYNTHESIS OF OPTICALLY PURE 2-AZIRIDINEMETHANOLS - VERSATILE SYNTHETIC BUILDING-BLOCKS

Authors
FUJII N NAKAI K HABASHITA H HOTTA Y TAMAMURA H OTAKA A IBUKA T
Citation
N. Fujii et al., SYNTHESIS OF OPTICALLY PURE 2-AZIRIDINEMETHANOLS - VERSATILE SYNTHETIC BUILDING-BLOCKS, Chemical and Pharmaceutical Bulletin, 42(11), 1994, pp. 2241-2250
Citations number
58
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
11
Year of publication
1994
Pages
2241 - 2250
Database
ISI
SICI code
0009-2363(1994)42:11<2241:SOOP2->2.0.ZU;2-G
Abstract
Synthesis of three cis-tl ans pairs of N-sulfonylated-2-aziridinemetha nols starting from (S)-threonine, (R)-allothreonine, a chiral 2-amino alcohol, or enantiomerically enriched 2,3-epoxy alcohols is described. A synthetic route to N-tosyl- and N-mesyl-2-aziridinemethanols from ( R)- and (S)-serines is also presented.