MODELING DRUG-RELEASE FROM GRANULES COATED WITH AN AQUEOUS-BASED SYSTEM OF ACRYLATE METHACRYLATE - EFFECT OF MOISTURE-CONTENT ON THE KINETICS OF DRUG-RELEASE

A simple model, which can be used to analyze data of the controlled re lease of a water-soluble drug from spherical particles coated with an aqueous-based system of acrylate methacrylate by a tumbling fluidized bed process, is presented. This model predicts that the fractional rel ease of a drug is related to the exponential of release time. Drug rel ease data of several samples prepared by various levels of operational moisture content were studied by the analytical equations, and the ef fect of operational moisture content on film thickness and permeabilit y of a drug sere investigated. It was found that the experimental resu lts were very web represented by the analytical equations, and the mec hanism of an aqueous coating was elucidated.