The relationships between fueling (gas injection and pellets of variou
s sizes and velocities), pumping in the divertor chamber (constrained
by fuel processing and divertor design), core density (constrained by
the desired fusion power and helium ash accumulation), separatrix dens
ity (constrained by divertor operation and density Limits) and plasma
confinement models are examined for the International Engineering Toka
mak Reactor (ITER) Engineering Design Activity (EDA) for guidance in t
he definition of design requirements for the pumping and fueling syste
ms. Various combinations of gas and pellet injection are found to meet
the constraints for operation at 1500 MW of fusion power and 1 bar.l/
s (5.3 x 10(22) atoms/s) of DT pumping. Very low pumping reduces fuel
processing requirements, but can lead to excessive helium accumulation
depending on the particle transport properties. Isotopic tailoring of
the fuel sources, e.g., 20-30% of the input fuel stream as tritium pe
llets and the rest as deuterium gas, can maintain the core fuel specie
s mixture in the optimum range for fusion production (at least a 40-60
mixture) while reducing the tritium concentration in the edge region
to 20-30%. This should reduce the tritium inventory in the plasma faci
ng components, since that is typically governed by the fuel density mi
x near the plasma edge. A high density, low temperature ignited regime
supported by deep pellet injection is shown to exist under some low c
onfinement conditions.