OPTIMIZATION OF RECOMBINANT ESCHERICHIA-COLI FED-BATCH FERMENTATION FOR BOVINE SOMATOTROPIN

Authors
YOON SK KWON SH PARK MG KANG WK PARK TH
Citation
Sk. Yoon et al., OPTIMIZATION OF RECOMBINANT ESCHERICHIA-COLI FED-BATCH FERMENTATION FOR BOVINE SOMATOTROPIN, Biotechnology letters, 16(11), 1994, pp. 1119-1124
Citations number
10
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
16
Issue
11
Year of publication
1994
Pages
1119 - 1124
Database
ISI
SICI code
0141-5492(1994)16:11<1119:OOREFF>2.0.ZU;2-Z
Abstract
Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batch E. coli fermentation with a controlled specific growth rate. Maximum specific bST concentra tion based on cell mass decreases linearly with the controlled specifi c growth rate. Productivity of bST is expressed by a quadratic equatio n as a function of the specific growth rate and has a maximum value at mu = 0.23 hr(-1).