Purpose: To describe the clinical features, surgical management, and o
utcome of patients with uveal melanoma who presented with or later dev
eloped a rhegmatogenous retinal detachment. Methods: We retrospectivel
y identified four patients who presented with uveal melanoma and rhegm
atogenous retinal detachment: simultaneously and six patients in whom
a rhegmatogenous retinal detachment developed 11-100 months (mean, 44.
8 months) after radiotherapy for a choroidal melanoma. Results: All fo
ur patients with simultaneous presentation of uveal melanoma and retin
al detachment underwent successful retinal detachment repair (cases 1
and 4, scleral buckle; case 2, pars plana vitrectomy, and case 3, pneu
matic retinopexy). Rhegmatogenous retinal detachment occurring after p
roton beam or plaque radiotherapy of uveai melanoma was repaired succe
ssfully in five of six patients with scleral buckling alone or in comb
ination with pars plana vitrectomy. In the short follow-up period of t
his study, we did not observe tumor recurrence either before or after
retinal detachment repair. Conclusion: Rhegmatogenous retinal detachme
nt associated with uveal melanoma may be treated successfully using co
nventional retinal surgical techniques. The benefits of retinal detach
ment repair must be weighed against any theoretical increased risk of
extrascleral extension of the melanoma, tong-term follow-up evaluation
will be required to determine the safety of Various retinal detachmen
t repair techniques in these eyes.